SYNTHESIS OF NOVEL SCHIFF BASES OF 5-AMINOSALICYLIC ACID BY GRINDING TECHNIQUE AND ITS EVALUATION FOR ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES

Abstract

5-Aminosalicylic acid or Mesalamine are considered as amino derivative of salicylic acid with molecular formula C7H7NO3. It is proved to a useful drug in an effective treatment of inflammatory bowel disease. It possess both anti-inflammatory and analgesic activity by targeting COX, Prostaglandins and lipoxygenase enzyme. Presence of primary amine group in the 5^th position makes them an important substrate for Schiff base synthesis. Schiff base possess diverse biological activities and can be formed by various methods. In the present study grinding technique was used as a simple and effective way for synthesizing Schiff bases of 5-Aminosalicylic acid. A mixture of aromatic aldehyde and 5-Aminosalicylic acid were grinded to produce yellow coloured Schiff base and free amine group forms double bond with the carbon forming a condensation product. Further these schiff bases were evaluated for anti- inflammatory and analgesic activities. m-Chloro derivative was proved to be a potent analgesic and anti-inflammatory agent.