DIVERSE PHARMACOLOGICAL ACTIVITIES OF 3-SUBSTITUTED COUMARINS: A REVIEW

Abstract

Coumarins belong to the family of lactones having benzopyrone system that can be isolated from plants as well as total synthesis can be carried out in the laboratory. To date, many chemical reactions have been established that can be used to synthesize coumarins like Knoevenagel condensation, Perkin, Pechmann, Reformatsky and Wittig reactions. Coumarins have attracted considerable attention of medicinal chemists and pharmacologists in recent years as they have been demonstrated to bear many pharmacological activities like anti-inflammatory & analgesic, antimicrobial, antioxidant, anticancer, analgesic & ulcerogenic, anticonvulsant, antihyperlipidemic, tyrosinase inhibitor and anti-parkinsonism activity. The aim of the present paper is to review the available information on 3-substituted coumarins.