EVALUATION OF ANALGESIC ACTIVITY OF LEPIDAGATHIS CRISTATA WILLD LEAF EXTRACTS

Abstract

Aim of the study is to screen the Lepidagathis cristata Willd, leaf extracts for analgesic activity, because the plant was screened only for immunosuppressive, antipyretic activities only, now in the present study the analgesic activity of leaf extracts were performed. The ethanolic, ethyl acetate, chloroform extracts were prepared and are used for analgesic activity in two dose level that is 200 and 400 mg/kg body weight per oral in two screening methods, one is Hot Plate (n=5), another is Tail Immersion method (n=5), and the leaf extracts are showed significant analgesic activity. The plant extracts did not exhibit any mortality up to the dose level 4000 mg/kg. The methanol, Chloroform and Ethyl acetate extracts of leaf was evaluated for analgesic activity. . The 400mg/kg dose of leaf chloroform extract has highest activity in both the experimental models with 62.5% protection after 30min and 47.3% after 60 min with the significance of p< 0.001 when compared with 0 time interval and after 90 min it was shown 50% of protection and all the extracts has graded dose response.