CURRENT TECHNIQUES IN PULSATILE DRUG DELIVERY: A REVIEW

Abstract

The purpose of writing this review on pulsatile drug delivery system (PDDS) is to compile the recent literatures with special focus on the different types and approaches involved in the development of the formulation and classification, advantages, limitation, and future aspects of pulsatile drug delivery system. PDDS is gaining a lot of interest as they deliver the drug at the right place at the right time and in the right amount, thus providing spatial and temporal delivery and increasing patient compliance. These systems are designed according to the circadian rhythm of the body. The principle rationale for the use of pulsatile release of the drugs is where a constant drug release is not desired. A pulse has to be designed in such a way that a complete and rapid drug release is achieved after a lag time. In this article, various systems like capsular systems, osmotic systems, single and multiple-unit systems based on the use of soluble or erodible polymer coating and use of rupturable membranes have been dealt. It summarizes the latest technological developments (including Wirelessly Controlled Drug-delivery MicroChip), formulation parameters, and release profiles of these systems.