SECOND ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF TELMISARTAN AND METOPROLOL IN TABLET DOSAGE FORM

Abstract

Accurate, precise, rapid and economical method was developed for the estimation of Telmisartan (TELM) and Metoprolol (METO) in bulk and tablet dosage form using second order derivative spectrophotometry. Wavelengths selected for quantitation were 299.5 nm for Telmisartan (zero crossing point of Metoprolol) and 224nm for Metoprolol (zero crossing point of Telmisartan). Linearity was observed in the concentration range of 3-15μg/ml for both Telmisartan and Metoprolol. The accuracy and precision were determined and found to comply with ICH guidelines. The proposed method was successfully applied for the simultaneous estimation of both drugs in commercial tablet preparation.