NOVEL ANALYTICAL METHOD FOR IMPROVEMENT OF AQUEOUS SOLUBILITY OF CANDESARTAN CILEXETIL USING CO-SOLVENCY APPROACH

Abstract

The present study was aimed at improving the aqueous solubility of candesartan cilexetil, a poorly water soluble drug, using poly ethylene glycol (PEG) 400 as co-solvent. It was observed that use of 5 % PEG 400 as co-solvent significantly improved the solubility by 50 folds. Beer’s law was obeyed in the concentration range of 4-20 μg/mL. Regression value for the calibration curve at wave length 232 nm was close to 1. The analysis of tablets by the proposed method indicated good correlation between estimated and label claim. The results of recovery studies revealed that any small change in the drug concentration could be accurately determined by the proposed method. The low values of limit of detection (LOD) and limit of quantification (LOQ) of candesartan cilexetil in PEG 400 indicated good sensitivity of proposed method. As PEG 400 was cheaper and less toxic when compared to organic solvents, this can be used as a substitute for organic solvents in the analysis. Thus the method developed to improve aqueous solubility of poorly water soluble drugs was found to be economical, eco-friendly, accurate, precise and can be applied in the routine analysis of tablets.