SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NEW ISATIN DERIVATIVES

Abstract

In search of novel  antimicrobial agents, a new isatin derivatives(5a-b)have been synthesized by heterocyclization of 5-substituted ethyl-((2-oxo-1
piperedin-1-ylmethyl)indolin-3-ylidene) hydrazinyl)acetohydrazide(4a-b) on treatment with CS2 in ethanolic KOH. Compounds synthesized have been 
characterized by IR spectroscopy and elemental analysis. In addition, the in vitro antimicrobial activity have been  tested against  E. coli, P. aeruginosa, 
Bacillus cereus, S. aureus and C.albicans by employing the well diffusion technique. The synthesized compounds were showing good antimicrobial 
activity and from comparisons of the compounds, compound 5b were found to be the most active compound.