DEVELOPMENT AND CHARACTERIZATION OF CHITOSAN NANOPARTICLES LOADED WITH AMOXYCILLIN

Abstract

This work presents result of the development and characterization of nanoparticles for entrapping Amoxicillin, an anti microbial agent. The present study was to focus on the development of amoxicillin loaded chitosan TPP nanoparticles. Chitosan concentration and drug polymer ratio in the nanoparticles influence the physicochemical characteristic such as zeta potential, poly disparity index, and average nano size diameter or percentage encapsulation efficiency of amoxicillin. An ionization method was used to entrap amoxicillin in a chitosan-matrix. The particle size analysis indicates a uniform particle size. The encapsulation efficiency decreased with increased of amoxicillin and chitosan concentration. The drug entrapment efficiency of nanoparticles having same ratio of polymer and drug was about 88%. The physical stability of nanopaticles was good as studied over a period of three weeks. The study of the release of drug from nanoparticles exhibited a prolonged release profile (79%) as studied over 28 hr. the drug release was constant showed that formulation was long term treatment. These studies showed that chitosan can complex TPP to form stable nanoparticles for amoxicillin loading, which can be useful for microbial therapy.