ASSOCIATION OF SERUM PREPTIN LEVELS WITH INSULIN RESISTANCE IN IRAQI WOMEN WITH GESTATIONAL DIABETES MELLITUS

Abstract

Gestational Diabetes Mellitus (GDM) is one of the most common metabolic disorders of pregnancy. This disease is characterized by an abnormal 
glucose tolerance recognized for the first time during pregnancy due to a decreased insulin sensitivity combined with insufficient insulin secretion. To 
estimate preptin concentrations in pregnant with gestational diabetes mellitus comparison with healthy pregnant. A total of 45 pregnant were divided 
into pregnant women with gestational diabetes mellitus(n=30) and  healthy pregnant (n=15)with gestational age-matched serum levels of biomarkers 
and cytokine were measured in second and third trimester  using Oral Glucose Tolerance  Test [OGTT]preptin and insulin levels were measured with 
ELISA. Metabolic parameters were measured by spectrophotometer methods. The correlation coefficients between serum preptin levels and age, BMI, 
insulin resistance, insulin sensitivity were also evaluated. Serum preptin levels were significantly high in Patients with gestational diabetes mellitus 
(446.33±81.34) compared with control healthy pregnant (157.26±36.50) (P <0.001). The correlation of Preptin levels in GDM pregnant was negatively 
with insulin resistance, age, BMI and fasting blood glucose but positively with fasting insulin levels and insulin sensitivity. In summary, serum preptin 
concentration were increased in GDM pregnant compared with normal pregnant. Serum preptin concentration is associated with glucose tolerance 
status, insulin resistance, insulin sensitivity, Beta-cells functions disrupted