EVALUATION OF NOOTROPIC ACTIVITY OF POLYHERBAL FORMULATION SR-105 IN EXPERIMENTAL ANIMALS

Abstract

The main objective of the proposed work is to evaluate the beneficial effect of SR-105 on CNS mainly for its locomotor and nootropic activities in different experimental animal models like passive paradigm, sodium nitrite induced amnesia, lithium induced head twitches. Also evaluate anticholinesterase activity on rat’s brain. The LD₅₀ of SR-105 was found more than 2000 mg/kg as OECD guidelines no-425. No significant alteration in motor activity was observed with all the doses of formulation tested on Actophotometer. In case of passive avoidance paradigm all dose of polyherbal formulation have shown an increased step-down latency (SDL), decreased time spent in shock zone and no of errors. SR-105 also reverse sodium nitrite induced amnesia and decreases lithium induced head twitches. In the present study. Polyherbal formulation SR-105, showed elevation of acetylcholine level by significant reduction of cholinesterase activity in rat’s brain and ultimately improved memory. In the light of above, it may be worthwhile to explore the potential of this formulation in the management of Alzheimer patients.