EFFECTS OF AGEING ON LEVELS OF NT-PROBNP [AMINO TERMINAL-PRO BRAIN NATRIURETIC PEPTIDES] IN ELDERLY DIABETES MELLITUS TYPE-II FEMALES

Abstract

To investigate the serum NT-proBNP, as a biomarker of cardiovascular diseases-Left ventricular hypertrophy, in females with diabetes type-II and its association with conventional cardiovascular risk factors i.e., Total Cholesterol, Triglycerides, HDL-Cholesterol, LDL-Cholesterol, and Blood Glucose. NT-proBNP were measured by fluoroturbidometry method. 40 diabetes type-II females and 20 without diabetes age matched females selected. The correlations between NT-proBNP and other variables of cardiovascular risk factors were assessed. The levels of NT-proBNP concentration in diabetes type-II female patients were significantly elevated. The MDA concentrations of 40 subjects were high as compared to controls, P<0.001. NT-proBNP levels were significantly correlated (P<0.05) with conventional cardiovascular risk factors (age, Glucose, Total Cholesterol, Triglycerides, HDL-Cholesterol, LDL- Cholesterol, Urine Albumin, and blood pressure). Serum levels of NT-proBNP is currently one of the most commonly proposed as a choice of cardiac biomarker. Serum levels of NT-proBNP increased significantly in diabetes type-II female patients. It may be a good marker for Left Ventricular Dystrophy and an oxidative stress event that is implicated in various pathological conditions.