EVALUATING THE RELATIONSHIP BETWEEN GLYOXALASE 1 AND BLOOD LEVELS OF MAGNESIUM, MANGANESE, AND SELENIUM IN INDIVIDUALS WITH DIABETES MELLITUS
Keywords:
Advanced glycation end products, Diabetic complications, Methylglyoxal, Micronutrients, Nephropathy, Neuropathy, RetinopathyAbstract
Background: First of all, Glyoxalase-1 is an erythrocyte enzyme that is part of the glyoxalase system and aids in the catabolization of methylglyoxal. Additionally, AGEs (advanced glycation end products) are precursors to this enzyme. Glyoxalase levels affect the development of diabetes problems caused by elevated AGE and methylglyoxal levels. There is little information on the relationship between trace elements and glyoxalase-1 in diabetics.
Aim: The current investigation set out to assess blood levels of magnesium (Mg), manganese (Mn), and selenium (Se) in different groups based on how long each group had had diabetes mellitus.
Methods: In order to correlate the concentration of micronutrients with glyoxalase-1 levels, the current study compared the concentration of several micronutrients, specifically manganese, selenium, and magnesium, in two groups: Group I was non-complicated and had diabetes duration of ≤4 years, and Group II had complications and diabetes duration of > 4 years. There were a total of 252 subjects with diabetes in this group.
Results: Group II had considerably greater levels of selenium and glyoxalase-1 (52.26±5.42 ng/dL and 78.97±16.57 ng/dL, respectively, with p<0.001) than group I. Group I had considerably greater amounts of manganese and magnesium (p<0.001) than Group II. Glycated hemoglobin, selenium, and magnesium levels in study groups were shown to be substantially correlated with glyoxalase-1 levels, with p-values of 0.007, 0.02, and less than 0.001, respectively, whereas, manganese showed a non-significant association with glyoxalase-1 levels with p=0.72.
Conclusion: In individuals with diabetes, glyoxalase-1 is a good indicator of inadequate glycemic control. In diabetic people, there is a correlation between high levels of glycoxalase and the premature onset of problems. Serum magnesium, selenium, and manganese concentrations all show a decline as diabetes duration increases.
