DESIGN DEVELOPMENT AND EVALUATION OF MODIFIED RELEASE TABLET OF MONTELUKAST SODIUM BY DRY COMPRESSION AND TABLET COATING

Abstract

In this particular study tablets were prepared by the dry compression method using roller compactor. The compressed tablets were then coated with the HP 55 and HP 50 coating polymer in the various concentration. The dissolution was carried out in the USP Basket apparatus. The drug release profile was very different for all the formulation as the concentration of the coating polymer varied in all the formulation.