FORMULATE AND EVALUATE THE ORAL DISPERSIBLE TABLET OF ANTIDIABETIC DRUG TENELIGLIPTIN

Abstract

Orodispersible tablets (ODTs) are novel drug delivery systems that have the potential to significantly affect conventional dosage forms in terms of 
patient compliance, convenience, bioavailability, and time to action. Despite the fact that significant research has gone into developing ODT 
formulations and technologies, in order to produce newer, more expense technologies and better items, more research is needed in these major 
destinations. Because of the availability of new technologies, as well as good market acceptance and patient compliance, the potential of dosage forms 
is attractive. Pharmaceutical companies can use ODTs for new product lines or first-to-market products, which is a factor in technology. With the 
continuing development of new pharmaceutical excipients, more unique ODT technologies are likely to occur soon. Method -For the orodispersible 
tablet optimized formulation, a direct compression method was used. Result: The pure dosage calibration curve was created by dissolving the medication 
in ethanol and measuring the absorbance with a UV spectrophotometer set at 243.5 nm. The value of the slope was 1.025. Light microscopy was used 
to predict the size of teneligliptin particles. The average length and breadth of drug particles were 2.10 µm and 1.14µm. In-vitro drug release study 
profile of formulation demonstrated around 71 % of the drug diffused in 60 min., while the formulation 85 % of the rug release in 60 min.