EFFECTS OF DIABETES ON THE AMINO TERMINAL PROBRAIN TYPE NATRIURETIC PEPTIDE (NT-PROBNP) LEVELS IN ELDERLY PATIENTS
Keywords:
ALVD, asymptomatic left ventricular dysfunction, BNP, brain natriuretic peptide, LVD, left ventricular dysfunction, NT-proBNP, Amino terminal Brain Natriuretic Peptide, SBP, systolic blood pressureAbstract
The Amino terminal portion of the precursor of brain natriuretic peptide (NT-proBNP) has been reported to be elevated in left ventricular dysfunction. The NT- proBNP is a split product from the proBNP molecule, and its level in the circulation is not, as the mature Brain type natriuretic peptide, dependent on the peripheral number of brain natriuretic peptide (BNP) receptors. We aimed to test the hypothesis that asymptomatic left ventricular dysfunction (ALVD), as estimated by NT-proBNP, would be more prevalent in patients with type 2 diabetes without overt cardiovascular disease in comparison with matched control subjects. The study population consisted of [N=100] out of which 75 patients including Type-II diabetes and 25 matched control subjects aged 40–70 years heart disease from OPD Escorts Heart Institute and Research centre Okhla New Delhi. NT-proBNP was measured in plasma by competitive enzyme immunosorbent assay. Patients with type-II diabetes were shown to have higher NT-proBNP values than control subjects. NT-proBNP levels were independently related to diabetes after adjustment for age, sex, systolic and diastolic blood pressure, BMI, heart rate, drug treatment, serum creatinine, and cystatin-C. The secretion of NT-proBNP is increased in type-II diabetic patients, suggesting that type 2 diabetes is associated with a higher prevalence of ALVD. NT-proBNP may thus serve as a screening tool to select patients with type-II diabetes who could benefit from an echocardiographical examination
