MINI REVIEW: JOURNEY OF SOLID DISPERSION TECHNIQUE FROM BENCH TO SCALE

Abstract

Solubility is one of the greatest pitfalls in the design of drug delivery systems. Poorly-soluble drugs not only increases adverse reactions and cost of therapy but also reduces the bioavailability of the drug. Therapeutic effectiveness of a drug depends upon the bioavailability and ultimately upon the solubility of drug molecules. Many approaches have been discovered for the purpose, among them solid dispersion is most widely used due to marvellous potential for improving drug solubility, by improving bioavailability and dissolution rate. Although there is a great interest in solid dispersion systems from the past four decades to increase solubility of poorly soluble drugs, their commercial use has been very limited. This is due to many reasons such as difficult to incorporate into dosage forms, laborious and expensive methods of preparation, and stability of the drug and vehicle, primarily because of manufacturing difficulties and stability problems. Due to these hurdles, the solid dispersion technique has been seeing a setback. The present review focuses on these problems so that an elaborate research is carried out and the technique does not recede.