SYNTHESIS AND BIOLOGICAL EVALUATION OF AMIDE DERIVATIVES OF THIAZOLES AS ANTICANCER AGENTS

Abstract

In this study, a series of amide derivatives (11a-j) containing thiazole moiety were designed and synthesized. All these synthesized compounds were confirmed by 1HNMR, 13CNMR and mass spectral data. Further, these were evaluated for anticancer activity against three human cancer cell lines including MCF-7 (breast), A-549 (lung), and A375 (melanoma). Among them, compounds 11b, 11d, 11e, 11f and 11g were exhibited more potent activity than positive control.