ONE-POT SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF 2-AMINO-5- ARYL-5H-THIAZOLO [4,3-b]-1,3,4-THIADIAZOLESA series of 2-amino-5-aryl-5H-thiazolo[4,3-b]-l,3,4-thiadiazoles were synthesized by using aromatic aldehydes, thioglycolic acid and thiosemicarbazide.

Abstract

A series of 2-amino-5-aryl-5H-thiazolo[4,3-b]-l,3,4-thiadiazoles were synthesized by using aromatic aldehydes, thioglycolic acid and thiosemicarbazide. Equimolar mixtures of aromatic aldehydes with thioglycolic acid and thiosemicarbazide in H₂SO₄ transform into 2-amino-5-aryl-5H-thiazolo[4,3-b]-l,3,4- thiadiazoles. Structures of all synthesized compounds were confirmed by FTIR, ¹H NMR and mass spectral data. Their antitubercular activity has been studied. All the synthesized compounds have shown good antitubercular activity.