FERMENTATION, MEDIA OPTIMIZATION STUDIES FOR COENZYME Q10 PRODUCTION BY Saccharomyces cerevisiae

Abstract

To establish the fermentation process for CoQ10 production by using Saccharomyces cerevisiae with subsequent bioprocess media optimization studies. Coenzyme Q10 (CoQ10) is a vitamin-like nutrient that plays a vital role in cellular energy production. Coenzyme Q10, apart from playing an important role in electron transfer for ATP synthesis, also acts as antioxidant. Therefore it is preferred as a potential therapeutic supplement to many critical diseases besides being used as dietary supplement in the energy drinks, anti-aging etc. This has driven the demand for Coenzyme Q10 supply to meet the market requirements. The method adapted for Coenzyme Q10 is batch fermentation route and preferred over synthetic method due to low production cost, safe environmental issue. The optimization of media for better yield of CoQ10 during fermentation and it was found that a maximum CoQ10 5mg/600ml is obtained at 4% of limiting substrate, 150 rpm at 30^oC.