NANO-STRUCTURES FOR NON-VIRAL GENE DELIVERY FOR CANCER THERAPY: A REVIEW

Abstract

Gene therapy, in present scenario capitalizes for therapeutic cure to patrimonial and acquired diseases such as carcinoma. It is the point of attraction in research community which is leading to noteworthy development over past two decade. Although viral vectors are much efficient carrier of gene but due to safety and toxicity issues, such as risks of hypersensitive response as well as potential risk of insertion of foreign gene in the genome of the organism cell, viral gene delivery are a talk of the past. Today the use of non-viral vectors, for various kinds of healing, has been exaggerated for safe gene therapy, but on the other hand it also poses a limitation of inefficient gene delivery to target site. Non viral vector do not poses safety issues, but the transfection efficacy of the non-viral vectors such as cationic polymers, lipids, dendrimers, etc is considerably lower as compared to the viral vectors.