ANTIMICROBIAL ACTIVITY AND DFT STUDIES OF SYNTHESIZED 3- (5-CYCLOHEXYL–1,3,4- OXADIAZOL-2-YL)-N- SUBSTITUTED ANILINE DERIVATIVES

Abstract

In the present study, synthesized 3-(5-cyclohexyl -1,3,4-oxadiazol-2-yl)-N-substituted aniline derivatives were studied for their in vitro antibacterial activity against four bacterial strains like gram positive; Staphylococcus aureus, Bacillus subtilis, gram negative bacteria : Escherichia coli, Pseudomonas aeruginosa and antifungal strains like Candida albicans, Aspergillus Niger. All synthesized compound showed moderate to good antimicrobial activities. The fifteen synthesized compounds have been performed with DFT by using RB3LYP/ 311G (d, p) basis set.