FORMULATION AND EVALUATION OF DUAL-LAYERED OSMOTIC PUMP CONTROLLED-RELEASE TABLETS OF CEFIXIME

Abstract

Background: This study aims to formulate, optimize and evaluate the osmotic tablet of cefixime. It improves the site specification and provides the 
controlled release of drug once – a – day through this drug delivery system. Cefixime assumes a significant part in dissolvability restricts other than 
dissolvable sort. It might increase the bioavailability of drugs by the preparation of the osmotic tablet. Method: The forming core tablet does a 
formulation of Controlled Porosity Osmotic Tablets (CP1 – CP9) using an ingredient like sodium chloride, PVP K30, Microcrystalline cellulose various 
ratios. The coating of the core tablet is done by Cellulose Acetate, PEG 400, with statistical ratios. Result: On depending upon the various evaluation 
parameters like hardness, diameter, friability, weight variation, content uniformity, In vitro release, CP9 formulation gave better consequence. The 
percentage of drug release is >95%. The optimized CP9 batch showed a maximum correlation of 0.992 with a zero-order drug release kinetic model. 
Conclusion: A controlled release formulation of cefixime based on osmotic technology, were developed. The release from the developed formulation 
was independent of pH and agitational intensity of the release media; the formulation fitted well into zero-order kinetics, indicating the release to be 
drug load independent. Drug release was directly proportional to the initial pore level but inversely related to the membrane weight. The release was 
inversely associated with the release media's osmotic pressure, confirming osmotic pumping as the central mechanism of release.