COMPARATIVE IN VITRO RELEASE STUDY OF SOME COMMERCIALLY AVAILABLE FLUCONAZOLE TABLETS
Keywords:
Antifungal etc., comparative,, osage form,, Immediate release tablet, d,, Dissolution,, Fluconazole,Abstract
Sundry brands of same dosage forms are available in the Indian market with the common assertion that they are all bioequivalent. The main objective of the present study was to conduct the comparative dissolution studies of different brands of same dosage forms to determine whether all the formulations used were bioequivalent or significantly different. AnImmediate release tablets dosage form disintegrate rapidly after administration with enhanced rate of dissolution.Three different brands of Fluconazole (Antifungal) of 150 mg Immediate release tablets from different manufacturers were selected in the study and dissolution testing in 6.8 pH Phosphate buffer was conducted from each brands for 30 minutes by using dissolution testingapparatus USP type-II. The result show that all brand fulfill the specification of dissolution profile and Fumycin’ manufactured by Pfizer was comparatively betterdissolution than other Fluconazole tablets used in experiments.
