SCREENING OF HERBAL LEAVES EXTRACT OF BOUGAINVILLEA GLABRA FOR DIABETIC NEPHROPATHY IN RATS

Abstract

The main objective of this study was to investigate hypoglycemic effects of Bougainvillea glabra Leaves extract in Streptozotocin (STZ) induced hyperglycemic rats. The secondary objective of the study was to study effect of extract on biochemical parameters. Extract was prepared from leaves of Bougainvillea glabra by Soxhlet extraction method. Diabetes was induced in rats by using Streptozotocin and rats were divided into 6 groups namely control, Diabetic, treated groups at doses of 250 mg/kg, 500 mg/kg, 1000 mg/kg and Lisinopril treated group. Blood and Urine samples were collected for the estimation of Total Glycerides (TG), Serum Cholesterol, Total protein, Blood Urea Nitrogen (BUN), Serum Creatinine, Thiobarbituric acid reactive substance (TBARS) and Glutathione levels (GSH). The result showed positive effect of leaves extract to reduce hyperglycemia in treated group as compared to control group. Bougainvillea glabra extract at 1000 mg/kg dose showed efficient results.