FLOATING DRUG DELIVERY SYSTEM OF NSAIDS TO INCREASE GASTRIC RETENTION TIME IN UPPER PART OF GASTROINTESTINAL TRACT: A REVIEW
Keywords:
FDDS,, gastric retention,, gastric emptying time, floatation, in-vitro techniquesAbstract
Floating drug delivery system was to organize the recent journalism with unique focus on the principal mechanism of floatation to achieve gastric
retention. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design
single unit and multiple unit floating systems. In the recent decades, there have been numerous attempts to overcome the barrier like short gastric
residence times and unpredictable gastric emptying times. This review also summarizes the in –vitro technique of evaluation, all the pre-formulation
and post formulation evaluations criteria. These systems are useful to several problems encountered during the development of pharmaceutical dosage
form. In this review, the technologies of formulation and mechanism of drug release, advantage, application in drug delivery of floating systems are
discussed
