RECENT TRENDS IN TREATMENT AND VALIDITY OF SCREENING MODELS USED IN TYPE 2 DIABETES MELLITUS: A REVIEW
Keywords:
Animal screening models,, preclinical trial, NIDDM, Diabetes mellitusAbstract
Type II Diabetes mellitus (NIDDM) is a complex and metabolic disease that affects and presents a serious health problem for more than 100 million
people around the world. Genetics and the environment are the variables which affect NIDDM. Reasonable screening models of animals will easily
understand the pharmacological screening of different therapeutic agents. NIDDM animal models are acquired either naturally or caused by chemical
reagents or by dietary, surgical or combination manipulation. A significant number of new genetically engineered animal models, including knock-out,
transgenic, and tissue-specific knockout mice, have been designed for the Diabetes mellitus (D.M.) research in the past year. With regard to their
characteristic characteristics and processes by which they arise, this analysis focuses on the animal models of NIDDM. In addition, this analysis
explicitly discusses the optimal selection and use of various animal screening models for the treatment of NIDDM in preclinical research.
