A STUDY OF ANALOGY AND COLLATION OF INTRAVENOUS ONDANSETRON AND INTRAVENOUS RAMOSETRON FOR THE PREVENTION OF POST OPERATIVE NAUSEA AND VOMITING FOLLOWING MIDDLE EAR SURGERIES IN A SOUTH INDIAN TERTIARY CARE HOSPITAL : A PROSPECTIVE, RANDOMIZED, DOUBLE BLI

Abstract

Postoperative nausea and vomiting (PONV) are problems encountered after general anaesthesia. 5-HT3 receptor antagonists are commonly used to treat or prevent PONV. In our study, we have evaluated the efficacy and safety considering the analogy and collation between i.v Ondansetron (4mg) and i.v Ramosetron (0.3 mg) in patients undergoing middle ear surgery in a south Indian tertiary care hospital. We found that, the average PONV Impact Scale Score (ISS) and the average Visual Analogue Scale (VAS) for post-operative nausea and vomiting was 0.005 (p<0.05) for i.v Ondansetron (4mg) and 0.028 (p<0.05) for i.v Ramosetron (0.3 mg). The incidence of a complete response during 2-6 and 24-36 hour period was 64% and 78.7% for i.v Ondansetron (4mg) respectively with the primary outcome measure of 0.047 (p < 0.05). But the incidence of a complete response during 2-6 and 24-36 hour period was 66.7% and 81.3% for

i.v Ramosetron (0.3 mg) with the primary outcome measure of 0.041 (p < 0.05). Analogy and collation profile of adverse effects between i.v Ondansetron (4mg) and for i.v Ramosetron (0.3 mg) shows that i.v Ramosetron (0.3 mg) has less incidence of adverse effects than i.v Ondansetron (4mg). In our study, it is evident that i.v Ramosetron (0.3 mg) was not only potent but it was also more efficacious and safer alternative to i.v Ondansetron (4mg) to prevent PONV.