STUDY OF ANTIULCER ACTIVITY OF ROOTS OF ALANGIUM SALVIFOLIUM LINN. IN PYLORUS LIGATED RATS

Abstract

Different extracts of Alangium salvifolium Linn. roots were tested for its antiulcer activity in aspirin induced and pylorus ligated rats model. The effect was assessed by parameters like Total acidity(TA),Free acidity(FA),Peptic activity(PA), Ulcer Index(UI) .The antiucler activity of all extracts were compared to the standard drug ranitidine. The study showed that all extracts were showing reductions TA, PA, FA and UI among which the extract of petroleum ether showed significant reduction upon those parameters. Alangium salvifolium Linn (400mg/kg) (PE extracts) shows complete inhibition ulceration and results are at par with (5mg/kg) of ranitidine.