NEW POLYMERIC FILM COATING FOR COLON TARGETING AND ITS EVALUATION

Abstract

The major objective is to optimize the properties of new polymeric films based on blends of cellulose acetate and guar gum. Recently guar gum was shown to be highly promising polymer for the colon targeting drug delivery system. Cellulose acetate, a water-insoluble polymer can protect the core from the small intestinal pH and act as a reservoir type system. However, it is yet unknown how desired membrane properties, especially water uptake and dry mass loss kinetics as well as mechanical stability can be adjusted to the specific needs of particular drug treatment. Variation in the guar gum:cellulose acetate blends were made thereby highly efficient and easy application tools were identified altering the membrane’s properties.