CLINICOEPIDEMIOLOGICAL PROFILE AND QUALITY OF LIFE ASSESSMENT IN PATIENTS WITH PSORIASIS ATTENDING A DERMATOLOGY OUTPATIENT DEPARTMENT: A PROSPECTIVE OBSERVATIONAL STUDY

Abstract

ABSTRACT 
Background: Psoriasis is a chronic immune-mediated inflammatory skin disorder characterised by recurrent 
erythematous scaly plaques and a variable clinical course. Apart from visible cutaneous lesions, psoriasis may cause 
itching, scaling, discomfort, cosmetic concern, social embarrassment, and psychological distress. Assessment of disease 
severity and quality of life is therefore essential for understanding the overall burden experienced by affected patients. 
Aim: To evaluate the clinical profile, severity pattern, and quality of life among patients with psoriasis attending a 
dermatology outpatient department. 
Methods: A prospective observational study was conducted in the Department of Dermatology during the year 2020 
among 126 adult patients clinically diagnosed with psoriasis. Detailed histories of demographic characteristics, disease 
duration, precipitating factors, family history, addictions, and associated comorbidities were recorded. Clinical 
examination included evaluation of the type of psoriasis, site of involvement, nail changes, and joint involvement. Disease 
severity was assessed using the Psoriasis Area Severity Index (PASI), while quality of life was assessed using the 
Dermatology Life Quality Index (DLQI). Statistical analysis was performed using SPSS software version 22. The chi
square test and independent t-test were applied as appropriate. A p-value of less than 0.05 was considered statistically 
significant. 
Results: Male predominance was observed, with the majority of patients belonging to the 31–50-year age group. Chronic 
plaque psoriasis was the most common clinical type. Scaling and pruritus were the predominant symptoms. Moderate 
psoriasis was the most frequently observed PASI severity category. Moderate and severe quality of life impairments 
together were observed in a substantial proportion of patients. Severe psoriasis shows a significant association with severe 
DLQI impairment. Hypertension and diabetes mellitus were the most frequently observed associated comorbidities. 
Conclusion: Psoriasis is associated with significant clinical and psychosocial burden. Increasing disease severity 
adversely affects quality of life. Routine assessment using PASI and DLQI, along with screening for comorbidities and 
psychological difficulties, may help provide comprehensive care to patients with psoriasis.