ASSESSMENT OF THE SURVIVAL AND MORTALITY PREDICTORS IN PATIENTS WITH THROMBOCYTOPENIC PURPURA (TTP) ADMITTED TO THE CRITICAL CARE UNIT

Abstract

Background: Widespread microthrombosis is a feature of TTP, a multisystem illness that often puts afflicted individuals at risk for multiple organ failure. The results of critically sick patients with TTP treated in the intensive care unit are not well documented in the literature. Aim: The objective is to assess the factors that predict survival and death in patients with TTP who are hospitalized to the intensive care unit (ICU). The incidence of nosocomial infections in participants who had plasma exchange (PE) and those who did not was also compared in the research.  Methods: The research assessed severely ill people with TTP handled in an intensive care unit. Information was gathered from hospital data and records for every person who was included for further assessment. Non-parametric statistical methods were used for data reporting. The collected data was statistically examined in order to formulate the findings. Results: 34 of the 267 screened participants fulfilled the requirements for inclusion and underwent evaluation. The mortality rate among TTP individuals was 41.17% (n=14). The ratio of women to men was 7:3. Thrombocytopenia, anaemia, and lactate dehydrogenase levels were greater in non-survivors than in survivors, with 2124 (1939-3317) u/L vs 2985 (1902-3612) U/L with p=0.69, 21x101µl vs 17x101µl with p=0.61, and 7.4g/dl (5.9-8.7) vs 5.2g/dl (4.6-6.9) with p=0.04, respectively. 55.88% (n=19) subjects had AKI (acute kidney injury) whereas 57.89% (n=11) subjects survived Conclusions: The current study comes to the conclusion that females with high death rates are more likely to have TTP. In TTP victims, low haemoglobin, advanced age, and increased platelet transfusions are indicators of poor survival. The incidence of nosocomial infection was similar regardless of PE treatment.