INTRAVENOUS IRON SUCROSE IN ANTIOXIDANT STATUS AND OXIDATIVE STRESS IN ANEMIC PREGNANT FEMALES

Abstract

Background: The most prevalent nutritional deficiency among pregnant Indian women is iron deficiency anemia (IDA),
which can be treated orally or intravenously. Because free iron is known to produce the free radicals that contribute to
oxidative stress, intravenous iron supplementation may increase the chance of free iron entering the bloodstream.
Aim: The purpose of this study was to investigate the effects of intravenous iron sucrose on oxidative stress and antioxidant
state in pregnant women with iron deficient anemia.
Methods: Forty pregnant women with a confirmed diagnosis of moderate iron deficiency anemia with hemoglobin levels
between 7 and 9.9 g/dl were evaluated in this study. Intravenous blood samples were taken from each female both before and
after intravenous iron sucrose treatment in order to measure antioxidants such as reduced glutathione. superoxide dismutase
and catalase, and lipid peroxidation markers as malondialdehyde. The results were developed through statistical analysis of
the collected data.
Results: Following intravenous iron sucrose therapy, the levels of malondialdehyde significantly increased, according to the
current study's findings. The study's findings also revealed that following the treatment of iron deficiency anemia in the
participants, there were no appreciable changes in the levels of reduced glutathione or the activities of superoxide dismutase
and catalase.
Conclusions: Based on an increase in lipid peroxidation in pregnant females with iron deficiency anemia, the current study
shows that intravenous iron sucrose infusion is linked to oxidative stress. Antioxidant therapy might therefore be taken into
consideration during iron treatment.