Design, Synthesis, and Evaluation of Novel Bioactive Heterocycles and Their Sustained-Release Oral Formulation for Prolonged Antimicrobial Action

Abstract

Background:
Heterocyclic compounds represent an important class of bioactive molecules widely used in
antimicrobial drug development due to their diverse pharmacological properties. Conventional
antimicrobial therapies often require frequent dosing and may contribute to poor patient compliance
and increased antimicrobial resistance. Sustained-release drug delivery systems have emerged as
effective strategies to prolong therapeutic action and improve treatment outcomes.