ASSESS THE RELATIONSHIP BETWEEN OVARIAN VOLUME AND FASTING PLASMA INSULIN RESISTANCE AND LEVELS IN WOMEN WITH POLYCYSTIC OVARIES

Abstract

Background: Polycystic ovarian syndrome, or PCOS, is a lifestyle-related condition whose prevalence has been rising 
worldwide, including in India, and which calls for further research.  
Aim: The purpose of this study was to use a HOMA 2 model to evaluate how insulin resistance increases as ovarian size 
increases. Using hemostasis model assessment 2 (HOMA 2), the study evaluated the relationship between ovarian 
volume and fasting plasma insulin resistance and levels in females with polycystic ovaries. 
Methods: Transabdominal sonography was used to measure the ovarian capacity in 108 female PCOS patients. Blood 
samples were taken from each participant under very rigorous aseptic and sterile circumstances, and they were submitted 
to be tested for fasting plasma insulin levels and fasting blood sugar. Insulin resistance, insulin sensitivity, and beta cell 
function were evaluated using the HOMA 2 calculator. The collected data were subjected to statistical analysis. 
Results: The research participants' mean BMI was 25.55 kg/m2, and they were 26.1 years old. Male pattern pubic hair, 
clitoromegaly, acanthosis, acne, hirsutism, alopecia, and hoarseness of voice were observed in 1.85%, 48.15%, 75.92%, 
12.96%, 59.26%, 72%, and 79.6% of their respective research participants. 
Insulin resistance and BMI (p=0.02), fasting plasma insulin and total ovarian volume (p=0.003), and fasting plasma 
insulin and BMI levels (p=0.02) all showed a significant positive connection. Additionally, a negative correlation between 
insulin sensitivity and ovarian volume and a positive correlation between insulin resistance and large ovarian volume 
were observed.  
Conclusion: The current study comes to the conclusion that in females with PCOS, an increase in ovarian volume may 
be interpreted as a sign of increased insulin resistance. 
Keywords: obesity, polycystic ovarian syndrome, PCOS, insulin resistance, and insulin sensitivity