COMPARISON OF INTRACERVICAL FOLEYS CATHETER WITH EXTRA AMNIOTIC PGF2 ALPHA INSTILLATION AND INTRACERVICAL FOLEYS CATHETER WITH PGE1 VAGINAL PILLS FOR SECOND-TRIMESTER ABORTION

Abstract

Background: Pregnancy termination in the second trimester, or more specifically in women with scarred uteruses, is a 
very difficult scenario that is linked to a three to five times increased risk of maternal morbidity and death.  
Aim: Using an intracervical foleys catheter with additional amniotic PGF2 alpha instillation against an intracervical foleys 
catheter with PGE1 vaginal tablets for pregnancy termination starting in the second trimester was the goal of the current 
investigation. 
Methods: In order to meet inclusion and exclusion criteria, 80 subjects were randomly assigned to two groups of 40 
subjects each. Group I subjects were induced using a Foley's catheter balloon and a vaginal PGE2 tablet, while Group II 
females were induced using a Foley's catheter balloon and extra amniotic instillation of PGF2α. In order to create a 2 ml 
solution equivalent to 0.50 mg PGF2α, 5 mg of 1 ml PGF2α was injected every hour for 48 hours or until expulsion. The 
injection was made with 19 ml of normal saline. The subjects' readiness for expulsion or induction was evaluated. 
Results: The mean product expulsion interval for Group II females was 18.2±3.8 hours, considerably shorter than that of 
Group I females (26.0±8.2 hours), with a p-value of <0.005. Additionally, it was observed that 32 out of 40 Group II 
participants had expulsion within 24 hours and using just one ampoule.  
Conclusion: The current study comes to the conclusion that the combination of Foley's catheter balloon and additional 
amniotic instillation of PGF2α is a safe and efficient way to end second-trimester pregnancies in women.  
Keywords: prostaglandins, Foley's catheter, extra-amniotic, and second trimester