INVESTIGATING PROCALCITONIN'S EFFECTIVENESS AS A STRONG BIOMARKER FOR NONSEPTIC BACTERIAL INFECTIONS

Abstract

Background: The hormone calcitonin plays a critical role in maintaining calcium and phosphorus balance.  
Aim: Using a large sample of Indian participants, the current study assessed the procalcitonin test's capacity to distinguish between different bacterial (non-sepsis) aetiologies.  
Methods: During the designated research period, standard laboratory and clinical data collected from the Institute's Central Lab were used to evaluate the current study. The importance of serum biomarker C reactive protein was evaluated using the collected data. Total leucocyte count and procalcitonin test for early bacterial infection identification. 
Results: Compared to the population with gram-positive bacterial infections, the study found that a greater frequency of elevated procalcitonin levels was observed in instances of gram-negative bacterial infections, namely those caused by Klebsiella pneumoniae and Escherichia coli. 
Conclusions: The current study finds that, similar to a rise in TLC and CRP, which are considered the gold standard for blood biomarkers in any bacterial infection, there is an increase in PCT levels even in people with non-septic bacterial  infections. It is also observed that, regardless of gender, the rise in these biomarkers is comparable in gram-positive and gram-negative infected people. Additionally, compared to gram-positive infections, gram-negative infections have greater elevated PCT.