A study of association of lipid profile with primary open angle glaucoma in non-obese patients

Abstract

Background: Hyperlipidemia has been linked to glaucoma and elevated intraocular pressure (IOP).
Aim and Objective: To evaluate the association between serum lipid profile and Primary Open Angle Glaucoma (POAG) in non-obese patients.
Materials and Methods: This case–control study was conducted after approval from the Institutional Ethics Committee (IEC) and obtaining written informed consent. A total of 120 adults (>40 years) were enrolled: 60 non-obese POAG patients (cases) and 60 age-matched non-glaucoma subjects (controls). Serum lipid profiles were assessed using Vitros 5600, in accordance with the Declaration of Helsinki.
Results: Mean total cholesterol and triglyceride levels were significantly higher in non-obese POAG cases compared to controls (p<0.05), while mean high-density lipoprotein (HDL) levels were significantly lower (p<0.001). Elevated cholesterol levels were found to be significantly associated with POAG in non-obese patients (p<0.001).
Conclusion: Serum lipid abnormalities, particularly increased cholesterol and triglycerides with reduced HDL, are significantly associated with the risk of POAG in non-obese individuals.