COMPARISON OF LETROZOLE AND CLOMIPHENE CITRATE FOR OVULATION INDUCTION

Abstract

Background: There is a dearth of information in the literature currently available comparing letrozole and clomiphene citrate

as ovulation induction agents, especially in the Indian setting. This situation calls for more clinical study and data.

Aim: The purpose of this study was to compare how well letrozole and clomiphene citrate induce ovulation in females with

ovulatory dysfunction.

Methods: The current study evaluated 120 women with ovulatory dysfunction and infertility between the ages of 20 and 40

who were treated with letrozole or clomiphene citrate. Clomiphene citrate was given as a daily dose of 50 mg once daily for

five days, with the dose increased by 50 mg per cycle to a maximum of 150 mg when ovulation did not occur. The Letrozole

group (n=60) received a daily dose of 2.5 mg for five days, which was increased by 2.5 mg per cycle for a maximum of 7.5

mg when ovulation did not occur.

Results: The average age of the research participants in the letrozole and clomiphene citrate groups was 29.6 years and 31.42

years, respectively. Subjects in the letrozole group had significantly greater rates of pregnancy, endometrial thickness, and

ovulation than those in the clomiphene citrate group. The letrozole group had a considerably lower mean number of follicles

than the clomiphene citrate group. Both research groups experienced similar side effects.