COMPARATIVE MYCOBIOME PROFILING OF ORAL MUCOSA IN DIABETES PATIENT

Abstract

Background: Nearly 1.4 million people in India are diagnosed with diabetes mellitus each year, making it one of the most prevalent endocrine illnesses in the world. The illness may cause the immune system to deteriorate and raise the risk of infections and other microbial illnesses.  
Aim: Using molecular and phenotypic identification of years isolated, the current study sought to evaluate the mycobiome profile of the yeast in the oral cavity of people with or without type 2 diabetes mellitus as well as any potential correlation between oral candida species and HbA1c levels in diabetics. 
Methods: 128 participants between the ages of 18 and 70 were split into two groups according to their glycemic status: 68 were diabetic and 60 were not. For determination of various fungal species using morphological and molecular identification after isolation from mucosal oral cavity in Indian diabetic and non-diabetic subjects. 
Results: In both diabetics and non-diabetics, the study's findings showed nine common species. Diabetics have higher levels of isolated fungus than non-diabetics. The most prevalent species was Candida albicans, which was followed by K. marxsianus.  
Conclusion: The current study provides important information on the variety and distribution of commensal yeast in Indian individuals' oral cavities as well as the risk of infection transmission due to shifts in the microbial species composition in relation to health problems.