Formulation and Characterization of transdermal patches loaded with Naringin

Abstract

A Transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific
dose of medication through the skin and into the blood stream. The transdermal drug delivery
system is one of novel drug delivery system which overcomes the conventional dosage form and
offers controlled release of the drug into the patient. Naringin has poor bioavailability in the oral
dosage form so the transdermal patch of Naringin increases the bioavailability of the drug with
respect to the oral dosage form to reduce the inflammation with minimal drug content compliance
to the patient. The aim of the study is to develop a transdermal patch loaded with Naringin for the
purpose of inflammation. The formulation was achieved using Hydroxypropylmethylcellulose
(HPMC) and ethylcellulose (EC) as the polymeric release controlling matrix for sustain release of
the Naringin drug. The formulation development has been carried out through solvent evaporation
method with an objective to deliver the drug in systemic circulation through skin at predetermined
rate with minimal inter and intrapatient variation. Among the formulations developed(NGP1,
NGP2, NGP3, NPG4) formulation NGP4 shows significant results, thus confirms the aim of study.