EXAMINING PROCALCITONIN'S EFFECTIVENESS AS A POSSIBLE BIOMARKER IN BACTERIAL INFECTIONS THAT ARE NOT SEPSIS

Abstract

Background: The hormone calcitonin plays a critical role in maintaining calcium and phosphorus balance. Additionally,
procalcitonin is generated in a variety of organs during systemic inflammation, including bacterial infections. After 2-4
hours of stimulation, the procalcitonin level increases and peaks in 6-2 hours. However, the majority of the evidence in
the literature depends on bacterial infections brought on by sepsis.
Aim: In a sizable sample of Indian participants, the current study assessed the procalcitonin test's capacity to distinguish
between different bacterial (non-sepsis) etiologies.
Methods: During the designated research period, standard laboratory and clinical data collected from the Institute's
Department of Microbiology were used to evaluate the current study. The importance of the procalcitonin test, total
leucocyte count, and serum biomarker C reactive protein for early bacterial infection identification was evaluated using
the collected data. Greater frequency of elevated procalcitonin levels in gram-negative bacterial infections, especially
those caused by Escherichia coli and Klebsiella pneumoniae, compared to the group with gram-positive bacterial
infections.
Results: Even in patients with non-septic bacterial illnesses, PCT levels rise in tandem with TLC and CRP, which are
considered the gold standard for blood indicators of bacterial infections. It is also observed that, regardless of gender, the
rise in these biomarkers is comparable in gram-positive and gram-negative infected people. Additionally, compared to
gram-positive infections, gram-negative infections have greater elevated PCT.