PROSPECTIVE FUNCTION AND CARDIOPREVENTIVE EFFECT OF d-LIMONENE AGAINST ADRIAMYCIN-INDUCED MYOCARDIAL DYSFUNCTION IN ALBINO RATS

Abstract

Adriamycin (ADR) an effective cytotoxic anthracycline antibiotic used for treating many solid tumours shows limiting significant in cardiac dysfunction. Partial side effect of adriamycin was due to oxidative stress and produce free radicals generate cardiotoxicity. d-Limonene a powerful terpenoid found naturally in all citrus fruits which avert oxidative damage and protects from cardiac damage induced by ADR. The object of the present study is to evaluate preventive role of d-limonene against ADR-mediated myocardial dysfunction. d-Limonene (100mg/kg.b.w) was given orally for 2 weeks prior to ADR (15mg/kg.b.w). Serum enzymes, such as SGOT, SGPT, CPK, CK-MB, troponin and C-reactive protein, were evaluated as markers for myocardial damage. Cardiac markers, GSH and GSSH, were also determined. Significant amount of d-limonene administration down regulates the activities of marker enzymes gradually. Histopathological PAS staining were complete to assess glycoconjugates assertion during cardiac damage. Hence, the results suggest d-limonene protects ADR-induced oxidative damages and boost up anti-oxidant to fight against cardiotoxicity.