SYNTHESIS AND ANTIOXIDANT ACTIVITY OF 6-IMINO-4-(METHYLTHIO)-2-(PYRIDINE-3-YL)-6H- 1,3-THIAZINE-5-CARBONITRILE

Abstract

Synthesis of novel heterocyclic 6-imino-4-(methylthio)-2-(pyridin-3-yl)-6H-1,3-thiazine-5-carbonitrile (3) was prepared by condensing thionicotinamide (1) with bis(methylthio)methylene malononitrile (2) in DMF and potassium carbonate as catalyst. Compound (3) has methylthio group at fourth position, which is replaced by different nucleophiles such as substituted anilines, phenols, hetryl amines and compounds containing active methylene group to afford 4-substituted derivatives of compound (3). The newly synthesized compounds were characterized by IR, 1H-NMR, Mass spectral analysis. Furthermore, these synthesized compounds were tested for antioxidant activity. The result of antioxidant activity reveals that most of the compounds shows potent activity. The major advantage of this protocol is operational simplicity and high yield.